"什么意思"用英语可以有多种表达方式，具体如下：
What's the meaning？
What do you mean？
What does it mean？
What do you mean by saying so？
What is the interpretation of this？
What did you take his comments to mean？
这些表达方式可以根据具体的语境选择使用。例如，在对话中询问对方的意思时，通常使用"What do you mean？"；在解释或询问某个词或句子的意思时，可以使用"What's the meaning？"或"What does it mean？"。